Latest App Notes & Case Studies

App Note / Case Study
Accelerate Mass Spectrometry Data Processing With Advanced Software Solutions
This case study reveals how advanced chromatography data system upgrades can deliver up to 15-fold increases in data processing speed, enabling comprehensive analysis of 250 components in under four hours instead of multiple days.

App Note / Case Study
Streamline Laboratory Software Management With Automated Updates
This case study demonstrates how one organization reduced update time from 3–5 days to just 30 minutes for 200 computers while eliminating travel costs and minimizing downtime.

App Note / Case Study
Alliance iS Bio HPLC System: Intuitively Simple
The Alliance iS Bio HPLC System featuring MaxPeak High Performance Surfaces (HPS) Technology reduces unwanted system-analyte interactions to improve sample recovery, reproducibility, and sensitivity in your bioseparations.

App Note / Case Study
Alliance iS HPLC System Brochure
The Alliance iS HPLC System works with Empower Software and eConnect Column tag Technology to reduce common errors in the lab, improve reliability of analytical measurements, ensure data integrity, and increase your lab's efficiency and productivity.

App Note / Case Study
Evaluating the Ruggedness of the Alliance™ iS Bio HPLC System for SEC Separations
In this study, the Alliance iS Bio HPLC System with an XBridge™ Premier Protein SEC Column (250 Å, 2.5 µm, 7.8 x 300 mm) was evaluated for method robustness and compared to a legacy stainless-steel system and column (250 Å, 5 µm, 7.8 mm x 300 mm).

App Note / Case Study
Migrating Peptide Mapping Methods from the Arc™ Premier System to the Alliance™ iS Bio System with Gradient SmartStart Technology and Intelligent Method Translator App (iMTA)
Integrated features of the Alliance iS Bio HPLC System support seamless transfer of methods from Arc Premier systems with quaternary solvent manager and binary solvent manager configuration while preserving separation selectivity.

App Note / Case Study
Routine Monitoring of DNA/mRNA Therapeutics With the Alliance™ iS Bio HPLC System and Ultra Wide-Pore GTxResolve™ Premier SEC Column
When using Waters™ ultra-wide pore particle GTxResolve Premier SEC Column, the lower system dispersion of the Alliance iS Bio HPLC System offers comparable performance to the ACQUITY™ Premier UPLC™ System in SEC separation.

App Note / Case Study
Extended Analysis of mAbs Using Ion-Exchange Chromatography on the Alliance™ iS Bio HPLC System
In this study an Alliance iS Bio HPLC System is employed in a 30-day robustness test using a salt gradient IEX method.

App Note / Case Study
Monitoring Impurities Using a High Throughput Focused Gradient With the Alliance™ iS Bio System
In this study, a shortened focused gradient targeting an oxidized peptide and its native species was developed via mass confirmation and transferred to the Alliance iS Bio HPLC System which provides high throughput and efficient monitoring.

App Note / Case Study
Evaluation of Modern and Legacy HPLC Systems for the Size-Exclusion Analysis of Aggregation and Fragmentation in a Monoclonal Antibody Drug
In this work an Alliance iS Bio HPLC System, an Alliance e2695, and a competitive Bio-inert HPLC system are compared using a size-exclusion method for analysis of monoclonal antibody aggregation and fragmentation.
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