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Latest App Notes & Case Studies

Waters Alliance iS Bio HPLC System with touchscreen, shown in brochure highlighting intuitive simplicity for biopharma
App Note / Case Study

Alliance iS Bio HPLC System: Intuitively Simple

The Alliance iS Bio HPLC System featuring MaxPeak High Performance Surfaces (HPS) Technology reduces unwanted system-analyte interactions to improve sample recovery, reproducibility, and sensitivity in your bioseparations.
Waters Alliance iS HPLC System brochure showing instrument with touchscreen and tagline 'A new era of intuitive simplicity'
App Note / Case Study

Alliance iS HPLC System Brochure

The Alliance iS HPLC System works with Empower Software and eConnect Column tag Technology to reduce common errors in the lab, improve reliability of analytical measurements, ensure data integrity, and increase your lab's efficiency and productivity.
Waters application note on evaluating the ruggedness of the Alliance iS Bio HPLC System for size-exclusion chromatography separations
App Note / Case Study

Evaluating the Ruggedness of the Alliance™ iS Bio HPLC System for SEC Separations

In this study, the Alliance iS Bio HPLC System with an XBridge™ Premier Protein SEC Column (250 Å, 2.5 µm, 7.8 x 300 mm) was evaluated for method robustness and compared to a legacy stainless-steel system and column (250 Å, 5 µm, 7.8 mm x 300 mm).
Waters application note on migrating peptide mapping methods to Alliance iS Bio with SmartStart Technology and iMTA app
App Note / Case Study

Migrating Peptide Mapping Methods from the Arc™ Premier System to the Alliance™ iS Bio System with Gradient SmartStart Technology and Intelligent Method Translator App (iMTA)

Integrated features of the Alliance iS Bio HPLC System support seamless transfer of methods from Arc Premier systems with quaternary solvent manager and binary solvent manager configuration while preserving separation selectivity.
Waters application note on routine monitoring of DNA/mRNA therapeutics with Alliance iS Bio HPLC and GTXResolve Premier SEC Column
App Note / Case Study

Routine Monitoring of DNA/mRNA Therapeutics With the Alliance™ iS Bio HPLC System and Ultra Wide-Pore GTxResolve™ Premier SEC Column

When using Waters™ ultra-wide pore particle GTxResolve Premier SEC Column, the lower system dispersion of the Alliance iS Bio HPLC System offers comparable performance to the ACQUITY™ Premier UPLC™ System in SEC separation.
Waters application note on extended analysis of monoclonal antibodies using ion-exchange chromatography on Alliance iS Bio HPLC
App Note / Case Study

Extended Analysis of mAbs Using Ion-Exchange Chromatography on the Alliance™ iS Bio HPLC System

In this study an Alliance iS Bio HPLC System is employed in a 30-day robustness test using a salt gradient IEX method.
Waters application note on monitoring impurities with a high throughput focused gradient using the Alliance iS Bio System
App Note / Case Study

Monitoring Impurities Using a High Throughput Focused Gradient With the Alliance™ iS Bio System

In this study, a shortened focused gradient targeting an oxidized peptide and its native species was developed via mass confirmation and transferred to the Alliance iS Bio HPLC System which provides high throughput and efficient monitoring.
Waters application note on evaluating modern and legacy HPLC systems for size-exclusion analysis of antibody drugs
App Note / Case Study

Evaluation of Modern and Legacy HPLC Systems for the Size-Exclusion Analysis of Aggregation and Fragmentation in a Monoclonal Antibody Drug

In this work an Alliance iS Bio HPLC System, an Alliance e2695, and a competitive Bio-inert HPLC system are compared using a size-exclusion method for analysis of monoclonal antibody aggregation and fragmentation.
Waters application note on successful USP Insulin Assay method migration to the Alliance iS Bio HPLC System
App Note / Case Study

Successful Method Migration of USP Insulin Assay to the Alliance™ iS Bio HPLC System

In this work, the USP Monograph for Insulin Assay will be tested across multiple systems, evaluating both system suitability requirements and % API potency of the substance, USP Human Insulin RS.
Waters application note on evaluating system robustness of the Alliance iS Bio HPLC system using peptide mapping analysis
App Note / Case Study

Evaluation of System Robustness of the Alliance™ iS Bio System Using Peptide Mapping Analysis

In this study, the Alliance iS Bio HPLC System is evaluated for robustness over a period of 30 days using a long, shallow gradient peptide mapping method.
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