NovaSeq X Series: Optimized for Comprehensive Omic Solutions

The NovaSeq X Series delivers the scalable sequencing power and flexibility to support a broad range of methods for interrogating the genome, epigenome, transcriptome, and proteome. Engineered to output data with the highest integrity, the NovaSeq X Series makes even the most data-intensive research accessible with industry leading speed and throughput.

Suitable for both small data sets and large-scale multiomic studies, supporting multiple sample types, e.g. bulk, single-cell, and spatial. Preconfigured and customizable workflows provide flexibility to meet different user needs.

Multiple cycle kits support a wide range of scalable options. The NovaSeq X Plus System and 1.5B, 10B, and 25B flow cells enable data-intensive multiomic studies at a broader and deeper scale than ever before. Built on decades of innovation from a trusted partner in genomics, the NovaSeq X Series will enable your most ambitious ultra-high-throughput projects. These are our most powerful sequencers yet. Scale your studies with three flow cell types and up to 16 Tb output per run on the dual flow cell NovaSeq X Plus System or up to 8 Tb on the single flow cell NovaSeq X System. Ultra-high-density flow cells and ultra-high-resolution optics enable output of up to 26 billion single reads per flow cell.

The NovaSeq X Series is powered by XLEAP-SBS chemistry — an even faster, higher quality, and more robust version of Illumina’s proven sequencing by synthesis (SBS) chemistry. XLEAP-SBS chemistry delivers the highest level of data accuracy and performance, and the increased stability enables remarkable sustainability benefits. DRAGEN analysis, is available onboard or in the cloud, and provides award-winning accuracy for rapid, easy-to-use, and efficient genomic data analysis. Integrated into the NovaSeq X Series, DRAGEN onboard can run multiple secondary analysis pipelines in parallel. Perform up to four simultaneous applications per flow cell in a single run.

DRAGEN onboard offers world-class bioinformatics as a direct output from the NovaSeq X Series. Get variant call files instead of base call files directly from your sequencing system. Accelerate your sequencing turnaround time and reduce your data storage, transfer, and retrieval costs.

The NovaSeq X and NovaSeq X Plus systems were purpose-designed to be our most sustainable sequencing systems yet. Save time and money with a 90% reduction in packaging weight and waste, maximize lab storage space with compact cartridges and packaging, and save on disposal costs with more recyclable plastics with no dry ice or ice packs.

The innovations built into the NovaSeq X and NovaSeq X Plus Systems have the power to generate tens of thousands of whole genomes per year. 

Dream big. NovaSeq X Series can make it happen.