How To Optimize ICP-MS for Trace Element Analysis

A method development guide using triple quadrupole ICP-MS 2 Preface This method development guide includes an interactive periodic table of elements (page 8) to help navigate you through the options and best solutions to analyze a full suite of elements (non-naturally occurring elements excluded) in any sample matrix, using triple quadrupole ICP-MS. For each element, a brief description of the isotopes available for analysis as well as common and less common interferences will be included. Finally, a table will highlight how each of the elements can be successfully analyzed. A method development guide using triple quadrupole ICP-MS Example for the table format used throughout this document Element Barium Available isotopes 130Ba (0.11%), 132Ba (0.10%), 134Ba (2.42%), 135Ba (6.59%), 136Ba (7.85%), 137Ba (11.23%), 138Ba (71.70%) Ionization potential 5.21 eV (10.00 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (138Ba16 4 O) 2 1 3 1 All available isotopes with isocratic abundance are shown. The preferred isotope is shown in bold. 2 The ionization potential indicates potential ion yield. Numbers in parentheses indicate that double charged interferences can be formed by this element. 3 Resolution setting when triple quadrupole modes are used for analysis 4 Best and alternative choice for the analysis of a given element—potential changes in product ions are mentioned in parentheses. 3 A method development guide using triple quadrupole ICP-MS Introduction Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is recognized as a key technique for the analysis of trace elements in a wide variety of sample types. This is due to its outstanding speed, detection sensitivity and ability to achieve detection limits generally in the low ng/L concentration range for most of the elements in the periodic table. For a number of elements, in particular metals with low ionization potential and low natural backgrounds, detection limits in the pg/L range can be achieved, even under normal laboratory conditions. Using a suitable configuration of the sample introduction system, the introduction of even the most challenging sample types, such as soil digests or undiluted sea water (total amount of dissolved solids approximately 3.5%), is possible. ICP-MS is therefore considered the major technique for sensitive and high-throughput analysis. However, biased or false positive results are still of concern for operators, lab managers and researchers, and in many cases, the root cause is unresolved spectral interferences. This is especially true for monoisotopic or quasi-monoisotopic elements, such as arsenic, which is a key analyte in many regulated methods governing the safety of, for example, drinking water, foodstuffs or pharmaceutical products. After continuous improvement in interference removal through the use of single quadrupole ICP-MS instrumentation equipped with a collision/reaction cell (CRC) (such as the Thermo Scientific™ iCAP™ MSX ICP-MS), recent years have seen accelerated development of ICP-MS using triple quadrupole technology (such as the Thermo Scientific™ iCAP™ MTX ICP-MS). These systems further enhance data quality by allowing reactive gases to selectively eliminate interferences regardless of the sample matrix. Developments in hardware and software focusing on ease of use in routine trace elemental determinations have allowed for triple quadrupole ICP-MS to be adopted by increasing numbers of laboratories. Here, they are taking over analysis from established techniques, such as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and single quadrupole ICP-MS. The information shown in this guide, plus a wide variety of other, additional possible reactions for all elements in the periodic table, is stored in the Reaction Finder method development assistant included in the Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution Software and is accessible anytime for consistent method development, which can be ideal for inexperienced users. This includes optimized settings for all relevant parameters, such as reactive gases, possible product ions (if any) and Q1 resolution. 4 How plasma conditions and sample matrix influence the analysis One of the reasons for the wide applicability of ICP-MS as a technique for the analysis of trace elements is its high sensitivity combined with unique robustness, enabling the analysis of a variety of sample matrices without (or at least with reduced) matrix effects, in comparison to techniques such as organic mass spectrometry. Matrix effects caused by a change of the sample matrix still occur but can be reduced by choosing the right configuration of the sample introduction system and compensated for by using suitable internal standards. The matrix tolerance of ICP-MS is achieved as a result of the high plasma temperature enabling full decomposition of the sample matrix to (mainly) singly charged atomic ions, in the general form M+ . Every element with an ionization potential lower than the first ionization potential of argon (15.76 eV) should form ions in an argon generated plasma. However, the lower the ionization potential of an element is, the higher is the degree of ionization, and therefore the sensitivity. Some elements show 2nd ionization potentials well below the ionization potential of argon, so a significant formation of doubly charged ions is observed, which in turn can lead to interferences on other elements. Tuning the plasma to a high temperature allows rapid and effective decomposition of the sample matrix leading to robust and reliable analysis of complex sample matrices, such as food digests, drinking waters or soil digests. The actual temperature of the plasma is impossible to measure, but generally ranges between 6,000 and 10,000 K depending on the tuned conditions. For the iCAP MSX ICP-MS and iCAP MTX ICP-MS systems, the typical plasma temperature can be estimated to be between 7,500 and 8,000 K (using the standard sample introduction system). Factors influencing the plasma temperature include the RF power, the plasma gas flows, the size of the injector tube, etc. Also, the sample flow and the sample matrix play an important role, as a too high sample flow or a complex matrix may consume a significant amount of energy from the plasma and hence reduce the available energy for ionization of critical elements, especially those with elevated ionization potential (≥ 8 eV). The correlation between the degree of ionization and the ionization potential for a given plasma temperature can be calculated using the so-called Saha-Langmuir equation. Assuming a plasma temperature of 8,000 K, the following ionization efficiencies are typically observed (Table 1). Table 1. Dependency of the ionization efficiency from the ionization potential at a typical plasma temperature of 8,000 K Ionization potential Degree of ionization Examples Below 6 eV 100% Alkaline and alkaline earth elements, lower rare earth elements Between 6–8 eV Close to 100% Transition metals, noble metals, higher rare earth elements Between 8–10 eV Decreasing to about 50% Some metals such as zinc, palladium, cadmium, antimony, osmium, iridium, platinum, gold Semi-metals and non-metals (e.g., beryllium, boron, silicon, arsenic, selenium, tellurium) Higher than 10 eV Below 50% (10% @ 12 eV) Mercury as the only metal Non-metals like carbon, nitrogen, oxygen, sulfur and phosphorous, but also halogens such as chlorine and bromine The conditions of the plasma are often characterized by indicators such as the formation rate of oxides (using for example the 140Ce16O+ / 140Ce+ ratio) and doubly charged ions (using the M++/M+ ratio an element with a low 2nd ionization potential, such as Ba or Ce). However, these two factors are closely dependent on each other and it is not possible to tune an inductively coupled plasma to reduce both of them at the same time. An increase in the plasma temperature may help to reduce the amount of oxides formed, but it will increase the extent of formation of doubly charged ions and vice versa. Although a higher plasma temperature would allow for potentially higher sensitivity for elements with elevated ionization potential, a higher formation of doubly charged ions, leading to interferences, would be observed as well. Tuning (manual or automated) of an inductively coupled plasma for mass spectrometry therefore takes both into account. Generally, a well-tuned ICP-MS system achieves a formation of oxides of typically less than 2% (1.5%–2.0%), with doubly charged ions below 3.0% at the same time (typically between 2.5% and 3.0%). As many elements form oxides or doubly charged ions, a wide variety of interferences need to be overcome because of their formation in the plasma. 5 Spectral interferences and how to overcome them Spectral interferences commonly observed in ICP-MS include polyatomic ions, doubly charged ions or isobaric interferences. In some cases, with very intense signals observed on a mass adjacent to the analyte mass, an overlap of the neighboring signal might be observed as well. • Polyatomic interferences are formed through recombination of previously ionized atoms as the ion beam traverses the interface region (e.g., between sample and skimmer cone). Expansion into the vacuum (from atmospheric pressure to about 2 mbar and subsequently to 10-7 mbar in the mass analyzer) leads to cooling of the ion beam, and hence recombination reactions can occur. Polyatomic interferences may be formed from all elements present in the sample, but the most severe polyatomics are created from argon ions in conjunction with O+ , and H+ derived from the aqueous sample media, or if present, N+ , Cl+ , S+ derived from the acid matrix. • Doubly charged interferences are formed through secondary ionization of elements with particularly low ionization potential. As all mass spectrometers detect ions on the basis of their mass-to-charge ratio (rather than mass alone), they will impact analytes at half the mass of the interfering element. These interferences are however easy to recognize in a mass spectrum. Whereas polyatomic and doubly charged ions are formed in the plasma, and their signal level can, to some extent, be controlled by the plasma conditions, isobaric interferences are caused by other elements present in the sample sharing isotopes with identical mass number and cannot be influenced by the instrument at all. However, in most cases they can be corrected for using correction equations, provided that another isotope of the interfering element is available and is itself free from interferences. A common approach to interference removal is kinetic energy discrimination (KED, Figure 1): Interference removal is achieved using helium in the collision/ reaction cell. All ions traveling through the cell sustain collisions with helium, although through its inert nature, no chemical reactions are induced. A positive bias potential is applied between the CRC and the analyzing quadrupole, so only ions with sufficient kinetic energy remaining will exit the cell. Polyatomic Figure 1. Interference removal using kinetic energy discrimination on the iCAP MSX ICP-MS interferences will be efficiently suppressed as they have a higher collisional cross section and lose more kinetic energy along the way. KED is even more effective when used in combination with a low mass cut off to eliminate ions of lower mass in the CRC, in order to reduce the formation of additional interferences in the cell. KED is an effective tool for the removal of polyatomic interferences; however, other types of interferences, such as isobaric overlaps or doubly charged ions, are not eliminated. Triple quadrupole systems can also leverage KED in the same way as a single quadrupole ICP-MS. In KED mode on a triple quadrupole system, the first mass filtering quadrupole is operated as an ion guide only. He KED filters out unwanted polyatomic interferences, based on the difference in cross-sectional size of the analyte and polyatomic Low mass cut off filters out precursor ions; ions are then unable to recombine later in the QCell and backgrounds are reduced further 40Ar+ , 40Ca+ , 35CI+ , 16O+ ArCI+ , Ca(OH)2H+ Quadrupole isolates ions required for measurements Comprehensive interference removal is achieved Target analyte 75As+ Complex sample matrix 6 Triple quadrupole ICP-MS systems, such as the iCAP MTX ICP-MS, achieve a new level of data quality and confidence in the result, and hence allow a significant improvement for key elements. Interference removal based on triple quadrupole technology (also occasionally referred to as MS/MS) includes a mass filtration step before the collision/ reaction cell, removing all ions of lower and higher mass than the analyte and its interferences with identical mass-to-charge ratio. This initial mass filtration allows reactive gases to be used for interference removal, which can induce highly selective ion-molecule reactions between either the analyte or the interfering ions with the gas. This will lead to a change of the ions observed, and hence a second mass filtration step in the analyzing quadrupole will allow the interference to be fully eliminated. The process of interference removal on the iCAP MTX ICP-MS is illustrated in Figure 2. The decision on whether a mass shift of the analyte (a so-called mass shift reaction) occurs or whether the interfering ions will react (a so-called on mass reaction) highly depends on the reactive gas used. Different gases exhibit different reactivities to certain ionic species, in many cases forming simple product ions, such as oxides (addition of an atom of oxygen), but also in other cases, complex product ions. The latter is in particular observed with ammonia, allowing very selective ion/molecule reactions with a variety of elements, but also effectively reducing charged ionic species, such as some polyatomic species. The following gases are typically used in conjunction with triple quadrupole ICP-MS: • Oxygen (O2): O2 induces a variety of effective chemical reactions with different elements. For most cases, an oxidation reaction will occur, leading to a mass shift of the analyte (e.g., 75As will be converted into 75As16O). This allows for effective suppression of polyatomic as well as doubly charged ions. Differences in the reactivity towards oxygen can be used in order to remove isobaric overlaps, such as the removal of 87Rb from 87Sr. • Ammonia (NH₃): NH₃ can react in different ways. Whereas with some elements, such as titanium, it forms a wide variety of reaction products (for example [TiNH(NH3) x ], it can also effectively eliminate polyatomic (especially chlorine-based) polyatomics. The removal of isobaric overlaps is as well possible, for example, the elimination of 204Hg from 204Pb. • Hydrogen (H₂): Although used for reduction of the 40Ar2 + interference (affecting the detection of 80Se), the use of H₂ does not lead to a significant performance improvement on triple quadrupole ICP-MS systems. Some elements, such as chlorine or phosphorous, may react in a mass shift reaction (to form ClH2 + or PH2 / PH4 + ), the yield is often low in comparison to a mass shift reaction with oxygen. Nevertheless, for some applications, the use of H2 can be beneficial. In some cases, special analysis conditions can also help to improve the overall performance of the ICP-MS analysis. Figure 2. Possible reaction pathways in triple quadrupole ICP-MS Q3 set to product ion mass (m/z 111) Q3 set to product ion mass (m/z 91) Q1 set to analyte mass (m/z 111) Q1 set to analyte mass (m/z 75) Q2 filled with reactive gas (O2) Q2 filled with reactive gas (O2) MoO2 150 + Nd++, 150Sm++, 40Ar35Cl+ 95Mo 150 + Nd+ , 150Sm+ , 91Zr+ 95Mo16O+ forms higher oxide products such as MoO2 75As+ is converted into 75As16O+ 111Cd 91 + [AsO]+ 111Cd+ , 95Mo16O+ “On Mass” 75As+ , 150Nd++, 150Sm++, 40Ar35Cl+ “Mass Shift” 7 Out of the common practices for removing spectral interferences, there are a number of techniques that can allow significant improvements but may only be applicable for a very limited set of sample matrices: • Cold (or cool) plasma uses a reduction of the RF power from about 1,500 W to typically less than 700 W in order to reduce the plasma temperature and hence the ionization of argon. Cold plasma conditions will typically favor the ionization of elements with low ionization potential, especially alkaline and alkaline earth elements such as Na, K, or Ca. In conjunction with the reduced observation of argon-based polyatomic species, a significant reduction of backgrounds and detection limits is possible. However, cold plasma conditions can only be applied for pure samples without any matrix load, for example, in the impurity screening of process chemicals in the semiconductor industry. • Adjustable quadrupole resolution settings can help to reduce the intense signals obtained from the measurement of major components in a sample. The resolution of the analyzing quadrupole can typically be reduced from the standard setting of about 0.7 amu to about 0.3 amu almost instantly during the analysis. In addition, an increase of the resolution setting allows the negative effect of peak tailing of highly abundant signals adjacent to an analyte, more commonly known as abundance sensitivity of the mass spectrometric system, to be reduced. Continue on to the next pages to learn more about how specific elements can be analyzed by ICP-MS. 8 Back to Periodic Table Periodic table of elements Click on any of the elements in red to jump to the specific page to read more information on method development using triple quadrupole ICP-MS. 9 Back to Periodic Table Lithium, Beryllium, Boron Elements with low mass rarely benefit from the use of a reactive gas since interferences are rare and interaction with heavier gas molecules (such as O2 or NH3) would lead to a significant reduction of sensitivity. Generally, these elements can be analyzed using either standard (no cell gas mode) or KED mode. Although there is a loss of sensitivity in KED mode for these low mass ions, detection limits in the low ng/L range are still achievable as backgrounds are reduced as well. This enables a reduction of the overall run time for multi-element analysis as there is no need to include an additional switch to standard mode. Whereas beryllium is monoisotopic, both lithium and boron have two isotopes, of which the heavier isotope in both cases has a significantly higher abundance. The minor isotope of lithium is available as an enriched stable isotope standard and is allowed for use as an internal standard for low mass elements within a number of regulatory guidelines (such as EPA Method 200.8). For boron, interferences can arise from the presence of organic solvents (from peak tailing of the neighboring, very intense 12C signal) or in the presence of high levels of Mg (formation of 24Mg++ at mass 12 with tailing into 11B). The use of a second mass filtration step using Q1 can improve the resolution of the adjacent signal, even without the use of the CRC or any collision/reaction gas. Element Lithium Available isotopes 6 Li (7.50%), 7 Li (92.50%) Ionization potential 5.39 eV Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives SQ-KED SQ-N/A Element Beryllium Available isotopes 9 Be (100%) Ionization potential 9.32 eV Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives SQ-KED SQ-N/A Element Boron Available isotopes 10B (19.90%), 11B (80.10%) Ionization potential 8.30 eV Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives SQ-KED SQ-N/A, TQ-N/A 10 Back to Periodic Table Sodium Magnesium Sodium is monoisotopic at m/z 23. Although no significant interferences are expected, sodium is usually analyzed using KED mode (for example, in environmental or food samples) for attenuation of the high signals caused by its ubiquitous nature. This can also be combined with increased resolution of the analyzing quadrupole to further reduce the signal intensity and increase the dynamic range even more. Where trace or ultra-trace analysis is required (for example, in the semiconductor industry), the use of cold plasma conditions can lead to a significant improvement of detection sensitivity and limits of detection. Magnesium has three isotopes, of which 24Mg is the default choice for analysis. Although polyatomic interferences are unlikely to occur (with the exception of 12C2 + formed when analyzing organic solvents), there may be a potential bias caused by 48Ca++ in environmental samples, for example. Magnesium does show a reduced reactivity to O2 compared to higher alkaline earth elements, but the use of O2 followed by on mass analysis allows the aforementioned interferences to be comprehensively removed. Element Sodium Available isotopes 23Na (100%) Ionization potential 5.14 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED SQ-N/A, TQ-O2 (23Na) Element Magnesium Available isotopes 24Mg (78.99%), 25Mg (10.00%), 26Mg (11.01%) Ionization potential 7.65 eV (15.03 eV) Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (24Mg) 11 Back to Periodic Table Aluminum Silicon Aluminum is monoisotopic with its only isotope 27Al. This element may be interfered in carbon-containing solutions (arising from 12C14N1 H+ ), but generally it is not affected by significant overlaps. However, aluminum can show sample matrix related errors, such as high signal fluctuation in the case of low sample acidity, as a result of the formation of Al colloids under these conditions. Often times, the addition of a small amount of acid can help to overcome this potential issue. Silicon is one of the most difficult elements for ICP-MS analysis, mainly because of the ubiquitous nature of this element and the need to carefully control blank levels. The major potential interferent is nitrogen from ambient air (forming an 14N2 + interference on the major isotope of silicon, 28Si). Although other isotopes of silicon are less interfered (29Si and 30Si), their low natural abundance limits the attainable detection sensitivity. The choice of the most appropriate mode for analysis strongly depends on the sample matrix. Whereas for aqueous samples, the use of TQ-H2 (on mass reaction) allows effective suppression of the 14N2 + interferences, for organic solvents, the choice of TQ-O2 mode is superior. Silicon can react with O2 to form 28Si16O; however, 12C16O as a potential interferent would react likewise to form 12C16O2 with an equal m/z ratio. Therefore, detection of 28Si16O2 + often provides superior results. The best method for the analysis of silicon is the use of H2 , leading to charge neutralization of the polyatomic interferences, or the use of the minor 29Si isotope in conjunction with O2 . Element Aluminum Available isotopes 27Al (100%) Ionization potential 5.99 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED SQ-N/A, TQ-O2 (27Al) Element Silicon Available isotopes 28Si (92.23%), 29Si (4.67%), 30Si (3.10%) Ionization potential 8.15 eV Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-H2 (28Si), TQ-O2 (28Si16O2 ) 12 Back to Periodic Table Phosphorous Sulfur Phosphorous is an important element due to its role in nutrition. It is also a highly relevant element in life science applications, as it can act as a proxy for DNA or DNA fragments, or be used for the detection and quantification of post-translational modifications of proteins through phosphorylation. However, due to its high ionization potential and significant polyatomic interferences (principally 14N16O1 H+ ), the analysis of phosphorous is often limited by reduced detection sensitivity and elevated detection limits. Due to its monoisotopic nature, there are no less interfered alternative isotopes available. However, phosphorous reacts efficiently with O2 and hence the majority of polyatomic interferences can be separated on a triple quadrupole ICP-MS system with dramatically improved sensitivity. Sulfur is one of the most difficult elements to be analyzed using ICP-MS. Because of its high ionization potential, the ion yield is generally low, and in aqueous media, there are highly abundant interferences, such as 16O2 + . Although the interferences on 34S are less pronounced (16O18O), the sensitivity is also reduced considerably because of the lower abundance of the isotope. The use of O2 and a mass shift reaction forming 32S16O can substantially improve the detection limits (typically, sub ppb levels are achieved), but mass filtration is essential to avoid interferences on the product ion mass through 48Ti or 48Ca. Element Phosphorous Available isotopes 31P (100%) Ionization potential 10.49 eV Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (31P16O) SQ-KED, TQ-H2 (31P1 H2 ) Element Sulfur Available isotopes 32S (95.02%), 33S (0.75%), 34S (4.21%), 36S (0.02%) Ionization potential 10.36 eV Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (32S16O) SQ-KED (34S) 13 Back to Periodic Table Chlorine Potassium Chlorine is an untypical element to be analyzed using ICP-MS. This is mainly due to its high ionization potential leading to low ion yield from the plasma and hence low sensitivity. In addition, hydrochloric acid is often an integral part of sample preparation. Nevertheless, chlorine can be analyzed using ICP-MS, for example, to confirm its absence in process chemicals in the semiconductor industry. The principal interferences on Cl are 17O2 1 H+ on 35Cl and 36Ar1 H+ on 37Cl, with the latter interference being proportionately higher. The less interfered 35Cl isotope is also the more abundant, so it is preferred for analysis. The use of triple quadrupole systems is beneficial for Cl analysis because of a positive effect on sensitivity through ion focusing and acceleration in the CRC. Chlorine can form product ions with both oxygen (e.g., 35Cl16O+ ) and hydrogen (e.g., 35Cl1 H2 + ), the latter being less effectively formed as two subsequent reaction steps are required for its formation. Potassium has its main isotope at m/z 39. Due to the adjacent and highly intense signal caused by the main isotope of argon (40Ar), there may be a contribution at low K levels from peak tailing. However, there is also direct, onmass contribution from 38Ar1 H+ . If the analysis of potassium at ultra-trace levels is required, for example, in the semiconductor industry, cold plasma can be used to reduce the formation of both 40Ar+ and 38Ar1 H+ ions and hence allow more sensitive detection of K. Element Chlorine Available isotopes 35Cl (75.77%), 37Cl (24.23%) Ionization potential 12.97 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (35Cl16O) TQ-H2 (35Cl1 H2 ) Element Potassium Available isotopes 39K (93.26%), 40K (0.01%), 41K (6.83%) Ionization potential 4.34 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED Cold Plasma 14 Back to Periodic Table Calcium Scandium Calcium has several different stable isotopes with masses between 40 and 48. The most abundant isotope 40Ca is interfered through 40Ar and hence not accessible when using hot plasma conditions. For typical applications, although limited in abundance, the 44Ca isotope is used for analysis. The main polyatomic interferences on this isotope are caused through 12C16O2 + , 28Si16O+ . 27Al16O1 H+ or 32S12C+ , but there are also potential doubly charged overlaps with 88Sr++ or 89Y++. As for potassium, cold plasma can be used to reduce the formation of 40Ar+ ions and hence allow the analysis of the main isotope in cases where the sample matrix concentration is low. Scandium is very attractive as a potential internal standard for the transition metals, as it is normally not present in most samples. However, its moderate 2nd ionization potential may lead to the formation of 45Sc++ ions, affecting the detection of 23Na. Scandium can be interfered in the presence of phosphorous ( 31P14N+ ) and silicon (29Si16O+ ), which may lead to misinterpretation of system stability when it is applied as an internal standard. Another potential influence on scandium is zirconium, as its major isotope, 90Zr, may form doubly charged interferences. Element Calcium Available isotopes 40Ca (96.94%), 42Ca (0.65%), 43Ca (0.14%), 44Ca (2.09%), 46Ca (0.004%), 48Ca (0.19%) 1st Ionization potential 6.11 eV (11.87 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (44Ca16O), TQ-NH3 (40Ca) Element Scandium Available isotopes 45Sc (100%) Ionization potential 6.56 eV (12.8 eV) Q1 resolution 1 amu Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (45Sc16O) SQ-KED, TQ-NH3 (45Sc) 15 Back to Periodic Table Titanium Vanadium Titanium has a remarkable isotope pattern with a total of five stable isotopes, surrounding the most abundant isotope, 48Ti. Due to a potential isobaric overlap with 48Ca, and polyatomic interferences caused by 31P16O1 H or 32S16O+ in the presence of higher amounts of phosphorous and sulfur, respectively, the preferred choice on a single quadrupole system is often 47Ti or 49Ti. However, Ti reacts well with O2 and NH3. Whereas the use of oxygen alone would lead to the formation of CaO+ , and hence would not remove the interference of Ca (unless a combination of gases is used), titanium forms a variety of different product ions with NH3, the most abundant of them typically being Ti[NH(NH3) 3] + and Ti[NH(NH3) 4] + , with mass-to-charge ratios of 114 and 131, respectively. If calcium is present in the sample as well, the reaction with NH3 is therefore the preferred choice as Ca reacts only slightly with NH3. Vanadium has two stable isotopes, 50V and 51V, with 51V being significantly more abundant. However, vanadium is strongly affected by interferences caused by chlorine through the formation of 35Cl16O+ . This interference can be removed using KED or the use of a reactive gas (O2 or NH3). Whereas O2 leads to a mass shift (51V16O+ ), the use of NH3 improves the removal of the ClO interference because V is not reactive towards NH3, it can be measured on mass when this reaction gas is used. In the presence of higher amounts of sulfur, in most samples unlikely formed 34S16O1 H polyatomic interference can become a potential issue, fully removable through the use of triple quadrupole technology. Element Titanium Available isotopes 46Ti (8.00%), 47Ti (7.30%), 48Ti (73.80%), 49Ti (5.40%), 50Ti (5.50%) Ionization potential 6.83 eV (13.58 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (48Ti16O), TQ-NH3 (114[ 48TiNH(NH3) 3]) Element Vanadium Available isotopes 50V (0.25%), 51V (99.75%) Ionization potential 6.75 eV (14.66 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (51V16O) SQ-KED, TQ-NH3 (51V) 16 Back to Periodic Table Chromium Manganese Similar to vanadium, chromium has one major isotope (52Cr) and alternatives with lower abundance. The main isotope is mostly interfered by 40Ar12,13C+ in carbon-rich sample matrices and, less heavily, by chlorine-based interferences (e.g., 35Cl16O1 H or 37Cl16O). Like vanadium, KED will efficiently remove the polyatomic overlaps, while O2 and NH3 also allow the detection sensitivity to be increased. When using O2 as a reactive gas, a mass shift reaction is induced, whereas the element is measured on mass in conjunction with NH3. Although monoisotopic manganese is not affected by a major argon-derived interference (40Ar14N1 H+ is relatively low and 40Ar15N⁺ is almost negligible due to the low abundance of 15N), there are interferences that need to be considered for certain sample types. In sample matrices containing higher amounts of potassium, the detection of manganese may be affected by the formation of 39K16O+ . Samples containing elevated amounts of iron (such as whole blood) may lead to peak tailing of the neighboring isotopes 54Fe and the more abundant 56Fe. Whereas the polyatomic interferences are easy to remove, the removal of the peak tailing of iron will significantly benefit from the use of triple quadrupole technology with either O2 or NH3 (as manganese is not reactive to either of the gases), in combination with an increase of the resolution setting of the analyzing quadrupole mass filter. Element Chromium Available isotopes 50Cr (4.35%), 52Cr (83.79%), 53Cr (9.50%), 54Cr (2.37%) Ionization potential 6.78 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (52Cr16O) SQ-KED, TQ-NH3 (52Cr) Element Manganese Available isotopes 55Mn (100%) Ionization potential 7.43 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 , TQ-NH3 (55Mn) 17 Back to Periodic Table Iron Cobalt Iron has four stable isotopes, of which 56Fe is the most abundant. However, when analyzing iron on a single quadrupole ICP-MS, often the less abundant isotope 57Fe is the preferred choice, since 56Fe is overlapped by an intense polyatomic interference, 40Ar16O+ . This interference can be reduced using KED, but signal-to-noise ratio is often still favoring the alternative isotope. However, this overlap can be efficiently reduced when applying a reactive gas such as O2 or NH3. In this case, the argon-based polyatomic interference will be neutralized in the cell, hence allowing the use of the most abundant isotope of iron. Cobalt is monoisotopic at mass 59. Due to its low ionization potential and the absence of any significant argon-based polyatomic interferences, it can be analyzed with high detection sensitivity using kinetic energy discrimination. The presence of high amounts of nickel can lead to biased results through peak tailing (58Ni and 60Ni surrounding 59Co) and 58Ni1 H+ formation, which can be resolved through the use of a reactive gas or the use of high resolution settings. Cobalt shows only a moderate reaction efficiency with oxygen, so an on mass measurement is the preferred choice when selecting triple quadrupole-based modes. Element Iron Available isotopes 54Fe (5.80%), 56Fe (91.72%), 57Fe (2.20%), 58Fe (0.28%) Ionization potential 7.90 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 , TQ-NH3 (56Fe) Element Cobalt Available isotopes 59Co (100%) Ionization potential 7.88 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (59Co), TQ-NH3 (59Co) 18 Back to Periodic Table Nickel Copper The main isotope of nickel is 58Ni; however, the preferred isotope in many cases is 60Ni to avoid an isobaric overlap with 58Fe. Nickel is not seriously affected through polyatomic interferences in the majority of typical sample matrices and does not show extended reactivity towards the main reactive gases commonly used in triple quadrupole systems. The main choice for analysis is therefore the use of kinetic energy discrimination, but the use of ammonia may help to improve detection sensitivity in an on mass measurement. Copper has two isotopes, 63Cu and 65Cu. Whereas normally 63Cu is the default choice, for the analysis of samples containing elevated amounts of sodium, the selection of 65Cu may be beneficial, as 63Cu can be affected by the formation of 40Ar23Na+ . Although the reactivity towards O2 is limited, copper does form several cluster ions with ammonia. However, on mass measurement is also possible. Element Nickel Available isotopes 58Ni (68.27%), 60Ni (26.10%), 61Ni (1.13%), 62Ni (3.59%), 64Ni (0.91%) Ionization potential 7.64 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 Element Copper Available isotopes 63Cu (69.17%), 65Cu (30.83%) Ionization potential 7.73 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 (95[ 63CuNH(NH3)]) 19 Back to Periodic Table Zinc Gallium Zinc has a total of five stable isotopes, with the default selection often being 66Zn due to the absence of isobaric overlaps. Zinc also has a slightly increased ionization potential, so ion yield is lower compared to other transition metals (e.g., Co). Whereas the element is limited in its reactivity to O2 , a product ion is formed with NH3 through the addition of one molecule of NH3 per atom (e.g., 83[ 66Zn(NH3)]). Higher amounts of sulfur present in a sample lead to the formation of 32S2 + and 32S34S+ , interfering on 64Zn and 66Zn, which may be an issue in some environmental samples, such as waste waters or flow back solutions. Gallium has two stable isotopes, 69Ga and 71Ga. The more abundant isotope can be seriously biased if the sample contains barium (the main isotope of barium is 138Ba and tends to form 138Ba++ easily). Polyatomic interferences are less pronounced, although a significant overlap could be observed through 55Mn14N+ . Gallium can be applied as an internal standard. Element Zinc Available isotopes 64Zn (48.60%), 66Zn (27.90%), 67Zn (4.10%), 68Zn (18.80%), 70Zn (0.60%) Ionization potential 9.39 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 83[ 66Zn(NH3)] Element Gallium Available isotopes 69Ga (60.10%), 71Ga (30.90%) Ionization potential 6.00 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 20 Back to Periodic Table Germanium Germanium is often used as a potential internal standard in a variety of applied applications, such as environmental analysis. Due to severe polyatomic and isobaric interferences on the major isotopes of germanium (e.g., 40Ar32S+ on 72Ge, 74Se+ on 74Ge, and Cl2 + on both 72Ge and 74Ge), it is most commonly analyzed using a minor isotope, 73Ge. If potential contributions from selenium can be excluded or are acceptably corrected through mathematical correction, 74Ge is an appealing alternative due to its significantly higher abundance. Although the use of triple quadrupole technology would remove the isobaric interference of selenium on 74Ge, the resulting sensitivity when using NH3 is often lower as compared to KED. However, germanium is also an analyte of high interest in the semiconductor industry and therefore needs to be analyzed at very low levels in process chemicals, such as different acids or organic solvents. Often, the use of triple quadrupole technology is superior to cold plasma as germanium has a relatively high first ionization potential. Element Germanium Available isotopes 70Ge (20.50%), 72Ge (27.40%), 73Ge (7.80%), 7 74Ge (36.50%), 76Ge (7.80%) Ionization potential 7.90 eV (15.94 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 (89[ 73Ge(14N1 H2 )]), TQ-O2 (73Ge) 21 Back to Periodic Table Arsenic Arsenic is monoisotopic at mass 75. Due to its toxicity, it is a mandatory element in many regulated methods. The most common interferences on arsenic are chlorine-based, such as either 40Ar35Cl+ or 40Ca35Cl+ , which can be efficiently reduced using KED. Additional interferences such as 150Nd++ or 150Sm++ can be observed when rare earth elements are present. This is often the case for soil samples, but food samples are also likely to be affected. The optimal way to resolve these interferences is the use of oxygen in the collision/reaction cell (leading to the mass shift formation of 75As16O+ ). Arsenic can also be present in a variety of different chemical forms, or species, varying dramatically in toxicity. The element is therefore a primary example for the need of speciation analysis in order to obtain information on the exact species present in a sample rather than the total concentration. Although potential interferences would be separated as well in the chromatographic separation, the use of triple quadrupole technology improves the overall sensitivity, enabling the detection of especially low abundant (and eventually otherwise missed) species. Element Arsenic Available isotopes 75As (100%) Ionization potential 9.82 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (75As16O) SQ-KED 22 Back to Periodic Table Selenium Selenium has six stable isotopes with varying abundances. The most abundant isotope, 80Se, is not the preferred choice due to the 40Ar2 + interference derived from the argon plasma. On single quadrupole instruments, the preferred choice is therefore a less abundant, but less interfered isotope, such as 77Se, 78Se, or 82Se. In addition, bromine can interfere on 80Se and 82Se through the formation of 79Br1 H+ and 81Br1 H+ . Like arsenic, doubly charged ions of certain rare earth isotopes, such as 156, 160Gd, can cause doubly charged interferences on the main Se isotopes. As with arsenic, the optimal way to resolve these interferences is to use O2 in the cell to mass shift Se to SeO+ . This approach enables use of the most abundant 80Se isotope, leading to drastically improved sensitivity and lower detection limits when using a triple quadrupole-based ICP-MS instrument. Element Selenium Available isotopes 74Se (0.86%), 76Se (9.23%), 77Se (7.60%), 78Se (23.69%), 80Se (49.80%), 82Se (8.82%) Ionization potential 9.75 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (80Se16O) SQ-KED (78Se), SQ-H2 (80Se) 23 Back to Periodic Table Bromine Like all halogens, bromine has a high 1st ionization potential, leading to low ion yield in an inductively coupled plasma. Nonetheless it can be analyzed with good detection limits. Bromine is even under regulation as it may form potentially carcinogenic BrO3 - as a byproduct in drinking water disinfection, requiring speciation analysis for separating other bromine-containing species such as bromide (Br- ). Bromine has two equally abundant isotopes, which may only be interfered through polyatomic species in the presence of high concentrations of transition metals such as copper (e.g., 63Cu16O+ and 65Cu16O+ ), or nickel (62Ni16O1 H+ and 64Ni16O1 H+ ). In addition, high concentrations of potassium may lead to the formation of 40Ar39K+ , again interfering with the commonly analyzed isotope, 79Br. In case the presence of rare earth elements is likely in a sample, the formation of doubly charged species of gadolinium (158Gd++), dysprosium (157Dy++ and 158Dy++) and erbium (162Er++) may affect the detection of bromine. Because of the higher abundance of gadolinium among all rare earth elements, 79Br is again likely more affected. However, because of its reactivity towards oxygen, all of the aforementioned interferences are safely removed using oxygen and a mass shift reaction. Bromine itself has the potential to interfere on 80Se and 82Se through the formation of hydrides (79Br1 H+ and 81Br1 H+ , respectively). Element Bromine Available isotopes 79Br (50.69%), 81Br (49.31%) 1st Ionization potential 11.81 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (79Br16O) SQ-KED, TQ-NH3 (79Br) 24 Back to Periodic Table Strontium Yttrium As with the majority of the alkaline earth elements, strontium forms a considerable amount of doubly charged ions and well as singly charged ions, leading to an interference on 44Ca (through 88Sr++). Out of its four isotopes, 88Sr is usually applied for analysis. In geochemical analysis, the isotope ratio of 88Sr/87Sr is of interest for age determinations. However, 87Rb creates an isobaric overlap, which can be removed through a mass shift reaction (forming 87Sr16O+ ) using O2 . Other gases, such as N2O or SF6 have been described for this application as well but are of limited use in a multi-element analysis. Yttrium is, like scandium or germanium, an element often recommended as an internal standard option in many regulatory methods. Typically, the formation of polyatomic interferences on its only isotope, 89Y, is rare, so even standard mode (no interference removal) allows interference-free detection. Element Strontium Available isotopes 84Sr (0.56%), 86Sr (9.86%), 87Sr (7.00%), 88Sr (82.58%) Ionization potential 5.70 eV (11.03 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (88Sr16O) SQ-KED Element Yttrium Available isotopes 89Y (100%) Ionization potential 6.22 eV (12.23 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (89Y16O) SQ-KED, TQ-NH3 (89Y) Rubidium Rubidium is a typical alkali metal with low first ionization potential but very high second ionization potential. Neither of its two isotopes is significantly interfered by polyatomic species, but its major isotope, 85Rb, can be slightly positively biased when using scandium as an internal standard (formation of 40Ar45Sc+ ). The low reactivity of rubidium to O2 (similar for all the alkali metals) can be used to resolve the potential isobaric overlap with 87Sr, by enabling 87Sr to be converted to SrO+ to move it away from 87Rb. Element Rubidium Available isotopes 85Rb (72.17%), 87Rb (27.84%) Ionization potential 4.18 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (85Rb), TQ-NH3 (85Rb) 25 Back to Periodic Table Zirconium Niobium The main isotope, 90Zr, makes up for more than half of all atoms of the element found in nature. Due to its unique properties, it is often applied in alloys and advanced materials, hence, it will often be analyzed in combination with other metals, which may be interfered by its presence (e.g., palladium or silver). Zirconium is very reactive with O2 and readily forms higher oxides (such as ZrO2 + , ZrO3 + ) as well as ZrO+ in the collision cell. This property is useful for removing ZrO+ and ZrOH+ interferences on Pd, Ag and Cd, which are not reactive towards oxygen. Niobium is monoisotopic at m/z 93. There are little polyatomic interferences to be expected under normal conditions, for example hydrides of zirconium or molybdenum (92Zr1 H+ and 92Mo1 H+ ), but also species of selenium formed in the plasma (e.g., 77Se16O+ ). An overlap by doubly charged ions of tungsten, rhenium or osmium might be possible but is unlikely based on the 2nd ionization potentials of these elements, all exceeding 16 eV (and therefore the ionization potential of argon) significantly. Niobium reacts with oxygen in a mass shift reaction and can therefore be easily analyzed free from interferences using a triple quadrupole ICP-MS. It also forms some product ions with ammonia, but the on mass reaction typically provides a better sensitivity. Element Zirconium Available isotopes 90Zr (51.45%), 91Zr (11.22%), 92Zr (17.15%), 94Zr (17.38%), 96Zr (2.80%) Ionization potential 6.63 eV (13.16 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (90Zr16O) SQ-KED, TQ-NH3 (90Zr) Element Niobium Available isotopes 93Nb (100%) 1st Ionization potential 6.76 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (93Nb16O) SQ-KED, TQ-NH3 (93Nb) 26 Back to Periodic Table Molybdenum Molybdenum has a number of stable isotopes between m/z 92 and m/z 100. Although potentially interfered by several oxides, nitrides or argides formed by other elements, all of these interferences can be efficiently reduced using KED. It is reactive with oxygen and can be analyzed via a mass shift process. This is used to remove molybdenum-based interferences on cadmium. Similar to zirconium, molybdenum is also very reactive to oxygen and forming higher oxides. Element Molybdenum Available isotopes 92Mo (14.84%), 94Mo (9.25%), 95Mo (15.92%), 96Mo (16.68%), 97Mo (9.55%), 98Mo (24.13%), 100Mo (9.63%) Ionization potential 7.09 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (98Mo16O) SQ-KED Silver Silver is increasingly being used in the production of nanomaterials with antibacterial properties in a variety of consumer products. This is leading to an increase of the amount of silver found in the environment, mostly in its ionic form Ag+ , but also as nanomaterial. Although its two isotopes are almost equally abundant, 107Ag is the preferred isotope for analysis. Silver is potentially interfered when metals such as zirconium or niobium are present. These elements form oxide (93Nb16O interfering on 109Ag) and hydroxide ions ( 90Zr16O1 H interfering on 107Ag), which can be efficiently removed using O2 . Silver is not reactive with O2 due to its noble chemical nature, and so the above interferences can be further oxidized and hence mass separated. Element Silver Available isotopes 107Ag (51.84%), 109Ag (48.16%) Ionization potential 7.58 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (107Ag) 27 Back to Periodic Table Cadmium Cadmium has a total of eight stable isotopes. Although 114Cd has the highest abundance, the preferred choice in ICP-MS is usually 111Cd due to the absence of isobaric overlaps with isotopes of palladium or tin, which affect all other isotopes of Cd. The most prominent interference on 111Cd is caused through 95Mo16O+ , but also zirconium can interfere (94Zr16O1 H+ ). As cadmium is not reactive towards O2 , an oxidation reaction of molybdenum (forming predominantly 95Mo16O2 + ) can be used in an on mass measurement. Element Cadmium Available isotopes 106Cd (1.25%), 108Cd (0.89%), 110Cd (12.49%), 111Cd (12.80%), 112Cd (24.13%), 113Cd (12.22%), 114Cd (28.73%), 116Cd (12.49%) Ionization potential 8.99 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (111Cd) Indium Indium is the only element in the periodic table that has no isotope free from isobaric overlap. Both isotopes, 113In and 115In, are interfered through other isotopes of either cadmium or tin. However, the abundance of 113In is significantly lower compared to 115In, so only the latter isotope is used for analysis. Indium is commonly used as an internal standard, but mathematical correction for Cd or Sn interference is feasible to avoid negative impact on the results, since polyatomic interferences or contributions of doubly charged ions are unlikely. Indium shows no significant reactivity to O2 , NH3 or H2 , so all measurement modes will be on mass. Element Indium Available isotopes 113In (4.30%), 115In (95.70%) Ionization potential 5.79 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (115In), TQ-NH3 (115In) 28 Back to Periodic Table Tin Tin is the element with the highest number of stable isotopes found in the periodic table with a total of 10 isotopes. Tin therefore causes a significant number of isobaric overlaps, which can in most cases be accounted for by using mathematical corrections. For ICP-MS analysis, there are two isotopes which are recommended for analysis, 118Sn and 120Sn, as these are the most abundant isotopes. Both are free from isobaric overlaps through other elements and little affected by polyatomic interferences in the most typical sample matrices. Tin is commonly analyzed using kinetic energy discrimination. It shows no significant reactivity towards the commonly used reactive gases. Element Tin Available isotopes 112Sn (0.97%), 114Sn (0.65%), 115Sn (0.36%), 116Sn (14.53%), 117Sn (7.68%), 118Sn (24.22%), 119Sn (8.58%), 120Sn (32.59%), 122Sn (4.63%), 124Sn (5.79%) Ionization potential 7.34 eV (14.63 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 (118, 120Sn) Antimony Antimony has two isotopes with similar abundance, and both are equally suitable for ICP-MS analysis. The use of kinetic energy discrimination is mostly sufficient for analysis, as polyatomic interferences will only be formed in the presence of certain elements, such as silver or palladium (as oxides or nitrides). Like tin, antimony does not show reactivity to either O2 , H2 , or NH3. Element Antimony Available isotopes 121Sb (57.30%), 123Sb (42.70%) Ionization potential 8.64 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 (121Sb) 29 Back to Periodic Table Tellurium Tellurium is an element occasionally used as an internal standard, but it is also becoming more important for analysis in environmental studies to better understand its toxicity and pathways as a contaminant. As a non-metal, its ionization potential is high, limiting the ion yield, and its most abundant isotopes are interfered by isobaric overlaps of xenon (128Xe on 128Te, having an abundance of 31.69%), and more importantly, barium on the most abundant isotope 130Te (with an abundance of 33.80%). However, using O2 as a reactive gas, xenon ions are efficiently removed from the ion beam, whereas barium ions undergo an oxidation and are hence separated in the analyzing quadrupole after reaction. Tellurium can therefore be detected interference-free using the most abundant isotope with triple quadrupole ICP-MS, whereas less abundant 125Te would be the common choice on a single quadrupole instrument. Element Tellurium Available isotopes 120Te (0.10%), 122Te (2.60%), 123Te (0.91%), 124Te (4.82%), 125Te (7.14%), 126Te (18.95%), 128Te (31.69%), 130Te (33.80%) Ionization potential 9.01 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (130Te) Iodine Iodine is monoisotopic in nature (127I), but has a few artificial isotopes, such as 129I or 131I, which are of analytical interest. These isotopes are long-lived and therefore subject to environmental forensic analysis. Due to the presence of Xe as a common impurity in argon gas, there is an isobaric interference on both 129I and 131I, which can be removed using O2 . Moreover, if trace analysis of 129I next to high amounts of natural iodine is required, significant backgrounds can be formed through the formation of 127I 1 H2 , which can be reduced using triple quadrupole instrumentation. Element Iodine Available isotopes 127I (100%), artificial isotopes 129I and 131I Ionization potential 10.45 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (127I) 30 Back to Periodic Table Cesium Cesium is monoisotopic at m/z 133 but has long-lived artificial isotopes, such as 137Cs, which are of interest in environmental forensics. Whereas 133Cs shows no significant interferences, 137Cs is interfered through an isobaric overlap with 137Ba. In order to separate the elements from each other, O2 can be applied, leading to a mass shift reaction of Ba and hence interference removal. Element Cesium Available isotopes 133Cs (100%), artificial isotope 137Cs Ionization potential 3.89 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (133Cs) Barium Barium is abundant in nature and has a total of seven isotopes. For the quantitative analysis of barium, either 137Ba or 138Ba are applied (using SQ-KED or TQ-O2 mode), but the other minor isotopes need to be considered as potential interferences on other elements, such as tellurium or cesium. Due to its low second ionization potential, barium is a likely interference on elements such as gallium through the formation of doubly charged ions. Element Barium Available isotopes 130Ba (0.11%), 132Ba (0.10%), 134Ba (2.42%), 135Ba (6.59%), 136Ba (7.85%), 137Ba (11.23%), 138Ba (71.70%) Ionization potential 5.21 eV (10.00 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (138Ba16O) 31 Back to Periodic Table Element Lanthanum Available isotopes 138La (0.09%), 139La (99.91%) Ionization potential 5.58 eV (11.06 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (139La16O) Element Cerium Available isotopes 136Ce (0.19%), 138Ce (0.25%), 140Ce (88.48%), 142Ce (11.08%) Ionization potential 5.54 eV (10.88 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (140Ce16O) SQ-KED Element Praseodymium Available isotopes 141Pr (100%) Ionization potential 5.46 eV (10.57 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (141Pr16O) SQ-KED Additional element descriptions follow on next page. The rare earth elements comprise a group of 14 elements (from lanthanum to lutetium) in the mass range between 139 and 176. Because of their high chemical similarity, these elements often occur in combination with each other, the most abundant single element out of the series being gadolinium. An exception is promethium, which does not occur naturally and is not included here. All rare earth elements are characterized by a low 1st ionization potential (yielding a high detection sensitivity at normally low backgrounds), but also a moderate 2nd ionization potential, leading to a variety of potentially occurring doubly charged interferences. Furthermore, all rare elements tend to form stable oxides, so although there is an isotope free from isobaric overlaps for each element, these polyatomic interferences can be of concern when measuring heavier rare earth elements in presence of their lower mass homologues. This is especially obvious for the determination of ytterbium in the presence of gadolinium. Both elements have an identical number of isotopes with almost identical abundances but are exactly 16 mass units apart. Therefore, the presence of gadolinium makes the determination of ytterbium at low levels very difficult. However, these elements also show different reactivities towards NH3, so resolution of the aforementioned interferences is possible using triple quadrupole ICP-MS. Elements such as Pr, Eu, Dy, Ho, Er, Tm and Yb do not (or only to a negligible extent) react with NH3, but oxide interferences are effectively removed. The remaining elements, La, Ce, Nd, Sm, Gd, Tb and Lu do react with NH3, but less effectively compared to the reaction with O2 . Often, a reaction with O2 (and hence the formation of the MO+ product ion) is the preferred choice. Element descriptions follow on next pages. Rare earth elements 32 Back to Periodic Table Rare earth elements continued Element Gadolinium Available isotopes 152Gd (0.20%), 154Gd (2.18%), 155Gd (14.80%), 156Gd (20.47%), 157Gd (15.65%), 158Gd (24.84%), 160Gd (21.86%) Ionization potential 6.15 eV (12.13 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (157Gd16O) SQ-KED Element Terbium Available isotopes 159Tb (100%) Ionization potential 5.86 eV (11.50 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (159Tb16O) SQ-KED Element Dysprosium Available isotopes 156Dy (0.06%), 158Dy (0.10%), 160Dy (2.34%), 161Dy (18.90%), 162Dy (25.50%), 163Dy (24.90%), 164Dy (28.20%) Ionization potential 5.94 eV (11.71 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (163Dy16O) SQ-KED Element Neodymium Available isotopes 142Nd (27.13%), 143Nd (12.18%), 144Nd (23.80%), 145Nd (8.30%), 146Nd (17.19%), 148Nd (5.76%), 150Nd (5.64%) Ionization potential 5.53 eV (10.78 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (144Nd16O) SQ-KED Element Samarium Available isotopes 144Sm (3.10%), 147Sm (15.00%), 148Sm (11.30%), 149Sm (13.80%), 150Sm (7.40%), 152Sm (26.70%), 154Sm (22.70%) Ionization potential 5.64 eV (11.09 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (149Sm16O) SQ-KED Element Europium Available isotopes 151Eu (47.80%), 153Eu (52.20%) Ionization potential 5.67 eV (11.25 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (153Eu) Additional element descriptions follow on next page. 33 Back to Periodic Table Element Holmium Available isotopes 165Ho (100%) Ionization potential 6.02 eV (11.82 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (165Ho16O) SQ-KED Element Erbium Available isotopes 162Er (0.14%), 164Er (1.61%), 166Er (33.60%), 167Er (22.95%), 168Er (26.80%), 170Er (14.90%) Ionization potential 6.10 eV (11.92 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (166Er16O) SQ-KED Element Thulium Available isotopes 169Tm (100%) Ionization potential 6.18 eV (12.02 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (169Tm16O) SQ-KED Rare earth elements continued Element Ytterbium Available isotopes 168Yb (0.13%), 170Yb (3.05%), 171Yb (14.30%), 172Yb (21.90%), 173Yb (16.12%), 174Yb (31.80%), 176Yb (12.70%) Ionization potential 6.25 eV (12.18 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (172Yb) Element Lutetium Available isotopes 175Lu (97.41%), 176Lu (2.59%) Ionization potential 5.43 eV (13.89 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (175Lu16O) SQ-KED 34 Back to Periodic Table Hafnium Tantalum Hafnium is rarely of interest for quantitation; however, Hf isotopes can be relevant in geosciences for the determination of the petrogenesis of igneous rocks and can be used to show crust or mantle mixing and weathering cycles. However, there are isobaric overlaps caused by ytterbium and tungsten on some of the key isotopes, which can be removed using NH3. Whereas ytterbium is close to unreactive to this gas, a variety of cluster ions are formed with hafnium, mostly following the general formula [Hf(NH2 )(NH3) x ], the most abundant one being [Hf(NH2 )(NH3) 3] + . Other rare earth elements, potentially more reactive towards NH3, are efficiently removed in the first quadrupole. For quantitative analysis, the selection of TQ-O2 mode using 178Hf is a viable way of assuring full interference removal and increasing the detection sensitivity. Tantalum is quasi-monoisotopic, as its major isotope, 181Ta, has an abundance of 99.99%. Tantalum is one of the rarest elements on earth, but it is used in a variety of applications, from electronic components to medical implants. Therefore, it is not commonly analyzed. The only relevant polyatomic interferences can be formed with rare earth elements, for example 165Ho16O+ , if Ho is present in the sample. However, Ta reacts efficiently with oxygen, so formation of 181Ta16O is a good way of eliminating the aforementioned Ho interference. Element Hafnium Available isotopes 174Hf (0.16%), 176Hf (5.21%), 177Hf (18.61%), 178Hf (27.30%), 179Hf (13.63%), 180Hf (35.10%) Ionization potential 6.83 eV (14.93 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (178Hf16O) TQ-NH3 (178[NH(NH2 )(NH3 ) 3 )] Element Tantalum Available isotopes 180Ta (0.01%), 181Ta (99.99%) Ionization potential 7.89 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives TQ-O2 (181Ta16O) SQ-KED, TQ-NH3 (181Ta) 35 Back to Periodic Table Tungsten Rhenium Tungsten has a total of five stable isotopes, of which 182W is the most common choice for analysis. As is generally the case in the high mass range, polyatomic interferences on W are rare, so in most cases, only isobaric overlaps are considered. Some isotopes of tungsten may be affected by oxide ions of less abundant rare earth elements, such as thulium or erbium. Tungsten itself may be found as an interference on mercury, especially through its major isotopes 184W and 186W (interfering as WO+ or WOH+ ions). Rhenium is occasionally used as an internal standard due its rare occurrence in nature, mostly using its minor isotope 185Re, which is not affected by isobaric overlaps. Element Tungsten Available isotopes 180W (0.13%), 182W (26.30%), 183W (14.30%), 184W (30.67), 186W (28.60%) Ionization potential 7.98 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 ( 265[ 182W(14N1 H)(14N1 H3) 4)] Element Rhenium Available isotopes 185Re (37.40%), 187Re (62.60%) Ionization potential 7.88 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (185Re), TQ-NH3 (185Re) 36 Back to Periodic Table Ruthenium Rhodium Ruthenium is commonly determined using the third most abundant of its seven stable isotopes, 101Ru. Other isotopes, such as the most abundant 102Ru, are affected by isobaric overlaps. Typically, there are almost no polyatomic interferences affecting the detection of 101Ru, so even standard mode (CRC used as an ion guide only) would provide accurate results. As with all platinum group metals, ruthenium is not reactive to O2 , but slightly reactive to NH3, forming a cluster ion through the addition of one NH3 molecule per atom. Rhodium is monoisotopic with its only isotope being 103Rh. It is often analyzed in order to assess purity of metals or metal alloys and can be interfered in the presence of high concentrations of Cu (63Cu40Ar+ ) and lead (206Pb++). Whereas the copper-based interference can be effectively removed using KED, the lead induced interference can only be removed using O₂ as a reactive gas, in which case, 103Rh will be determined on mass. Due to the frequent use of rhodium as an internal standard, interferences caused by higher concentrations of lead can be misinterpreted as an unexplained matrix effect. Element Ruthenium Available isotopes 96Ru (5.52%), 98Ru (1.88%), 99Ru (12.70%), 100Ru (12.60%), 101Ru (17.00%), 102Ru (31.60%), 104Ru (18.70%) Ionization potential 7.36 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED SQ-N/A Element Rhodium Available isotopes 103Rh (100%) Ionization potential 7.46 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (103Rh) Platinum Group Metals (PGMs) 37 Back to Periodic Table Palladium Osmium Palladium has a series of isotopes, the default selection often being 105Pd due to the absence of isobaric overlaps (caused by either ruthenium or cadmium). However, since 89Y is an element often used as an internal standard, there may be elevated backgrounds or false positive results observed through the formation of 89Y16O+ . Like most PGMs, Pd is unreactive towards O2 and can be analyzed interference-free on mass. Osmium has a total of seven stable isotopes, but despite the high number, 192Os still shows a reasonable abundance of 41.00%. However, due to isobaric interferences with 192Pt, the preferred isotope for analysis is often 189Os. Due to a similar reactivity of Pt and Os towards both O2 and NH3, the selection of this alternative isotope is the best option. Osmium is well known to be affected by physical interferences and losses occurring during sample preparation and analysis, especially because of its high volatility in its oxidized form (e.g., after a microwave digestion). As well as potentially being lost to the atmosphere on opening the digestion vessel, Os can also be volatilized preferentially in the spray chamber, which may lead to an overestimation when not calibrated using standards containing the same chemical form of Os. Element Palladium Available isotopes 102Pd (1.02%), 104Pd (11.14%), 105Pd (22.33%), 106Pd (27.33%), 108Pd (26.46%), 110Pd (11.72%) Ionization potential 8.34 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (105Pd) Element Osmium Available isotopes 184Os (0.02%), 186Os (1.58%), 187Os (1.60%), 188Os (13.30%), 189Os (16.10%), 190Os (26.40%), 192Os (41.00%) Ionization potential 8.71 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (189Os), TQ-NH3 (204[ 189Os(14N1 H)]) Platinum Group Metals (PGMs) 38 Back to Periodic Table Iridium Platinum Like all platinum group metals, iridium is analyzed as part of the composition and impurity analysis of ores and refined metals/alloy products. Iridium is also often used as a high mass internal standard. Its more abundant mass 193 isotope (193Ir) may be interfered by oxide or hydroxide ions of elements such as lutetium and hafnium, but by itself it can create an oxide interference on 209Bi. Similar to the aforementioned elements, interferences can be removed through the use of O2 , to which Ir shows only limited reactivity. The two most abundant isotopes of platinum are 194Pt and 195Pt (with 32.90% and 33.80% relative abundance), however, both may be interfered through hafnium oxide and hydroxide interferences. On mass measurements using O2 cell gas are an effective way to remove these interferences. In contrast to other platinum group metals, platinum also forms product ions with NH3, such as 229[ 195Pt(NH3) 2 ] + . Element Iridium Available isotopes 191Ir (37.30%), 193Ir (62.30%) Ionization potential 9.12 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (193Ir) Element Platinum Available isotopes 190Pt (0.01%), 192Pt (0.79%), 194Pt (32.90%), 195Pt (33.80%), 196Pt (25.30%), 198Pt (7.20%) Ionization potential 9.02 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (195Pt) or TQ-NH3 (229[ 195Pt(NH3) 2 ]) Platinum Group Metals (PGMs) 39 Back to Periodic Table Gold Mercury Gold is often used for stabilization and reduction of memory effects of mercury, commonly during the analysis of environmental samples (drinking waters or waste waters), food samples or pharmaceutical products. In recent years, it has started to be used in nanomaterial production and can therefore also be found increasingly in the environment. Gold is an important analyte for the assessment of the content or impurity levels in ores and metals/alloys, where its only isotope 197Au can be interfered by 181Ta16O+ . The determination of gold in materials containing platinum may be affected through hydride formation and peak tailing of the 196Pt and 198Pt isotopes, which can be reduced through the use of O2 in the collision cell in combination with high mass resolution on the analyzing quadrupole. Like platinum, cluster ions of identical composition can be formed with NH3 as a reactive gas. Mercury is a key element in many regulated methods due to its elevated toxicity. Out of its seven stable isotopes, the most abundant 202Hg is commonly applied for analysis. Occasionally, interferences caused through the presence of tungsten (forming for example 186W16O+ ) can be found to bias results. Similar to the removal of molybdenum interferences on cadmium, O2 can be used to convert WO+ species into WO2 + derivatives, whereas mercury is not reactive and can be determined interference-free on mass. Element Gold Available isotopes 197Au (100%) Ionization potential 9.23 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (197Au) or TQ-NH3 (231[ 197Au(NH3) 2 ]) Element Mercury Available isotopes 196Hg (0.14%), 198Hg (10.02%), 199Hg (16.84%), 200Hg (23.13%), 201Hg (13.22%), 202Hg (29.80%), 204Hg (6.85%) Ionization potential 10.44 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (202Hg) 40 Back to Periodic Table Thallium Lead Thallium is a highly toxic metal, having two isotopes, which normally can be considered interference-free. It shows limited reactivity to both O2 and NH3, but formation of product ions is less favorable compared to measuring unreacted Tl. Lead is an exception in the periodic table as its isotopic composition may vary considerably in different regions. This is because three out of the four stable Pb isotopes are formed through radioactive decay of uranium or thorium. It is common practice to calculate the sum of all isotopes rather than using the result of a single isotope for quantitation. The use of KED mode is the method of choice, as polyatomic interferences are seldomly observed for lead. An exception is the determination of lead isotope ratios, which is of high interest in geosciences. The variable formation of 206Pb, 207Pb and 208Pb is a wellaccepted way to determine the age of a rock. However, the 204Pb isotope (the only one not formed through radioactive decay) has an isobaric interference from 204Hg. Whereas a single quadrupole ICP-MS would have to rely on mathematical correction, triple quadrupole ICP-MS systems can fully eliminate the interference using NH3. Although lead is not reactive to NH3, Hg is efficiently removed. Element Thallium Available isotopes 203Tl (29.52%), 205Tl (70.48%) Ionization potential 6.11 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 , TQ-NH3 (205Tl) Element Lead Available isotopes 204Pb (1.40%), 206Pb (24.10%), 207Pb (22.10%), 208Pb (52.40%) Ionization potential 7.42 eV (15.03 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-NH3 (204-208Pb) 41 Back to Periodic Table Bismuth Thorium, Uranium Bismuth is monoisotopic and often used as an internal standard for heavy elements such as lead or mercury. It is normally not interfered and is unreactive to the common gases O2 , NH3 and H2 . However, it can be present as an impurity in some samples. Both these elements are only still present in nature because of the extremely long half-lives of some of their isotopes. Other isotopes may exist as decay products, but are often short lived and hence not relevant for quantitative assessment. For thorium, the 232Th isotope is the most stable, having a halflife of around 14 billion years. It is essentially monoisotopic in practice, but detectable levels of 230Th (with a half-life of 75 thousand years) have been found in deep ocean waters and sediments. For uranium, the 238U isotope (with a half-life of 4.5 billion years) has the highest mass and also the highest natural abundance of all U isotopes. The second most abundant isotope, 235U, has a half-life of 700 million years. Due to their low ionization potential, both elements can be measured with high ion yield and hence high sensitivity. For uranium, the use of O2 and subsequent conversion into 238U16O2 + is an option to improve sensitivity even further. Uranium can cause peak tailing onto adjacent masses (especially m/z 237 and 239), but the use of triple quadrupole technology also allows the impact of this tailing to be significantly reduced by mass filtration in Q1 and Q3, respectively, as well as by differential reactivity of isotopes such as 237Np and 239Pu towards O2 . Element Bismuth Available isotopes 209Bi (100%) Ionization potential 7.29 eV Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 , TQ-NH3 (209Bi) Element Thorium Available isotopes 232Th (100%), half life 1.405 x 1010 years 1st Ionization potential 6.08 eV (11.50 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (232Th) Element Uranium Available isotopes 234U (0.01%), 235U (0.72%), 238U (99.27%) half live between 2.5 x 105 and 4.5 x 109 years Ionization potential 6.19 eV (14.72 eV) Q1 resolution Intelligent Mass Selection (iMS) Preferred analysis modes Reaction Finder default Alternatives SQ-KED TQ-O2 (238U16O2 ) Conclusion The use of triple quadrupole ICP-MS offers new possibilities for the analysis of elemental contaminants. Whereas for some elements, the default selection of an analysis mode assuring full interference removal and best limits of detection is not different between single and triple quadrupole instruments, there are significant differences for a variety of other elements. In these cases, the use of triple quadrupole technology allows all types of interferences—polyatomic, doubly charged ions and isobaric interferences—to be removed. In addition, the use of reactive gases in combination with suitable bias settings between the CRC and analyzing quadrupole allows the achievable sensitivity, and hence 42 the detection limits, to be significantly improved. The use of triple quadrupole technology therefore allows analysis performance to be enhanced, although interference removal may not always be an issue for all elements. At the same time, for a large variety of elements, effective interference removal can be accomplished through the combination of only two measurement modes, SQ-KED and TQ-O2 . Even in high-throughput analysis laboratories, the added time per sample will only be on the order of a few seconds to accommodate the gas exchange between helium and oxygen. For advanced applications, or special interference challenges, the use of ammonia can be an attractive alternative, not only to allow highly selective and specific interference removal, but also to provide a further improvement of detection sensitivity. Find out more at thermofisher.com/icp-ms Our innovative ICP-MS solutions are designed to meet the needs of all laboratories, from high-throughput and routine to cutting-edge research facilities. With advanced performance for reliable and accurate data generation and simple, intuitive workflows for ease-of-use, our ICP-MS instruments enable you to work smarter now and be ready for future challenges. General Laboratory Equipment – Not For Diagnostic Procedures. © 2025 Thermo Fisher Scientific Inc. All rights reserved. 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