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From Plasma to Proteome: Scalable and Reproducible Approaches for Biomarker Discovery

Webinar

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Plasma proteomics holds immense potential for biomarker discovery, yet traditional approaches have been limited by the ability to detect only the most abundant proteins, highlighting the need for strategies to maximize plasma proteome coverage.

In this webinar, Dr. Sasha Singh and Duc Duong will highlight their respective research in addressing challenges in large-scale proteomics for biomarker discovery and identifying Alzheimer’s disease biomarkers.

Our expert speakers will showcase how an enrichment method can vary across plasma sources in large-scale proteomic studies and illustrate how optimized proteomic workflows can uncover reliable plasma biomarkers.

Attend this webinar to:

Discover how to efficiently prepare blood-derived human EDTA plasma samples for LC-MS based proteomic analysis
Explore how to implement reproducible and standardized plasma workflow with scalable throughput
Achieve comprehensive plasma proteome characterization, addressing the dynamic range challenge for deeper insights
Gain insights into strategies for maximizing plasma proteome coverage and optimizing sample preparation for high-quality, reproducible plasma proteomic profiling

Speakers

Sasha A. Singh, PhD

Assistant Professor of Medicine, Director of Proteomics Research

Brigham and Women’s Hospital, Harvard Medical School

Dr. Singh earned her MSc in Developmental Genetics and PhD in Biochemistry/Protein Crystallography from the Department of Cell and Systems Biology at the University of Toronto. Following her doctoral studies, she joined the labs of steen and steen at Children’s Hospital Boston and Harvard Medical School for training in mass spectrometry-guided research. A highlight of her work was the development of FLEXIQuant, a practical and effective workflow for implementing full-length protein mass spectrometry standards, which later evolved into a novel in vitro kinase assay known as FLEXIQinase. Dr. Singh joined the Center for Interdisciplinary Cardiovascular Sciences at Brigham and Women’s Hospital in 2012 and has been an innovative leader ever since. Her work has contributed significantly to the development of foundational research and target discovery platforms focused on understanding and tackling mechanisms of cardiovascular disease. Notably, Dr. Singh was the first to apply high-resolution, high-accuracy mass spectrometry to monitor protein turnover in humans. Her work has contributed to a paradigm shift in our understanding of “good HDL-cholesterol particle” metabolism. Her lab has extensive expertise in developing bench-to-instrument workflows for ADP-ribosylation proteomics, advancing the study of this critical modification and its role in cellular processes. Dr. Singh is a member of the American Society for Mass Spectrometry, the US Human Proteome Organization, the American Heart Association and the International Society for Applied Cardiovascular Biology.

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Assistant Professor of Medicine, Director of Proteomics Research

Brigham and Women’s Hospital, Harvard Medical School

Duc Duong

Core Director, Emory Integrated Proteomics Core (EIPC)

Emory University

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From Plasma to Proteome: Scalable and Reproducible Approaches for Biomarker Discovery